NLRP3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90949-50, BS90949-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96P20(Human) Q8R4B8(Mouse) EntrezGene:287362(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC, IP, , FC

All Applications: WB:1:1000
ICC:1:100-1:500
IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
IP:1:50-1:100

Background: Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NLRP3 polyclonal antibody detects endogenous levels of NLRP3 protein.

Bioworld Molecular Weight: 118/85 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of NLRP3 on human lung tissue lysates., ICC staining NLRP3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining NLRP3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CLR1.1, NLRP3, AGTAVPRL, AII/AVP, Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, LRR and PYD domains-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3, NLRP3, PYPAF 1, PYPAF1, PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified