CD68 Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1162-50, EM1162-100

Citations, Manuals and MSDS Available upon request.

Background: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.

Alternate Name: CD68 molecule, GP110, Macrosialin, SCARD1

Source: Mouse

Applications: IHC

Dilution: IHC 1:200-500

Reactivity: Human, Rat, Mouse

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Human Gene ID: 968

Human SWISS Prot NO: P34810

Subcellular Location: Cell membrane and Endosome membrane. Lysosome membrane

Research Use Only