MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats.

Product information

CAS Number: 1779796-36-9

Molecular Weight: 272.70

Formula: C15H10ClFN2

Chemical Name: 3-fluoro-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile; chlorohydrogen

Smiles: Cl.CC1=CC=CC(C#CC2C=C(C=C(F)C=2)C#N)=N1

InChiKey: WRHOKQFFLQKKNL-UHFFFAOYSA-N

InChi: InChI=1S/C15H9FN2.ClH/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12;/h2-4,7-9H,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5.

In Vivo:

MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats. MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake.

Products are for research use only. Not for human use.