JAK2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90750-50, BS90750-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O60674(Human) Q62120(Mouse) Q62689(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: ICC IHC

All Applications: ICC:1:50-1:200
IHC:1:50-1:200

Background: JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Purification and Purity: Peptide affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.

Bioworld Molecular Weight: 131 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining JAK2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-JAK2 antibody. Counter stained with hematoxylin.

Alternative Name: JAK-2, JAK2, JAK 2, JAK-2, JAK2, JAK2, Janus Activating Kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 2, JTK 10, JTK10, kinase Jak2, OTTHUMP00000043260, THCYT3, Tyrosine protein kinase JAK2, Tyrosine-protein kinase JAK2,

Immunogen: Peptide.

Conjugate: Unconjugated

Modification: Unmodified