Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.

Product information

CAS Number: 705946-27-6

Molecular Weight: 445.53

Formula: C26H28FN5O

Chemical Name: (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one

Smiles: CC1=CN=C(N1)/C(=C1\C(=O)NC2C=CC(=CC=2\1)NC1CCN(CC1)CC)/C1C=C(F)C=CC=1

InChiKey: DMQYDVBIPXAAJA-VHXPQNKSSA-N

InChi: InChI=1S/C26H28FN5O/c1-3-32-11-9-19(10-12-32)30-20-7-8-22-21(14-20)24(26(33)31-22)23(25-28-15-16(2)29-25)17-5-4-6-18(27)13-17/h4-8,13-15,19,30H,3,9-12H2,1-2H3,(H,28,29)(H,31,33)/b24-23-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 62.5 mg/mL (140.28 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Tyrosine kinase-IN-1 is from reference (compound 8K).

In Vivo:

Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.

Products are for research use only. Not for human use.