PLEKHG6 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-15225-60, E-AB-15225-120, E-AB-15225-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: PLEKHG6

Target Synonym: FLJ10665; MGC126315; MGC126353; MGC126354; Myosin interacting guanine nucleotide exchange factor; PH domain containing family G member 6; Pleckstrin homology domain containing family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6; PLEKHG6

Research Areas: Cancer, Cell Biology, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q3KR16

Background: PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Concentration: 0.1 mg/mL

Immunogen: Recombinant protein of human PLEKHG6

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 89kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only