TNFRSF14 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS6775-50, BS6775-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q92956

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:500~1:2000

Background: HVEM (herpes virus entry mediator A), also known as TR2, ATAR, HVEA, LIGHTR or TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), is a 283 amino acid single-pass type I membrane protein that is widely expressed, with highest expression in lung, spleen and thymus. A member of the TNF receptor superfamily, HVEM mediates the entry of herpes simplex virus (HSV) 1 and 2 into T lymphocytes by serving as an attachment site for the HSV envelope glycoprotein D (gD).HVEM acts as a receptor for two cellular ligands, secreted lymphotoxin and LIGHT. A member of the TNF superfamily produced by activated T-cell, LIGHT is suggested to induce apoptosis and suppress tumor formation. Consisting of three TNFR-Cys repeats, HVEM plays a critical role in HSV pathogenesis. HVEM is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TNFRSF14 polyclonal antibody detects endogenous levels of TNFRSF14 protein.

Bioworld Molecular Weight: ~ 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of HL-60 cell lines, using TNFRSF14 antibody.

Alternative Name: Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD270; TNFRSF14; HVEA; HVEM; UNQ329/PRO509

Immunogen: Recombinant full length Human TNFRSF14.

Conjugate: Unconjugated

Modification: Unmodified